Understanding how the endoplasmic reticulum helps make and manage proteins in mitochondria
Official title: Endoplasmic reticulum-assisted mitochondrial precursor biogenesis and quality control
Funded at Johns Hopkins University · NIH-11100340 · Data updated 2026-11-12
This study looks at how a part of your cells called the endoplasmic reticulum helps make and manage important proteins for your mitochondria, which are the energy factories of your cells, and it hopes to find ways to improve our understanding of mitochondrial diseases that could help patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 15, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $32,378 |
| NIH project number | 3R01GM151746-02S1 |
| Project ID | NIH-11100340 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with known mitochondrial dysfunction or related metabolic disorders.
✕Less likely to help
Patients with conditions unrelated to mitochondrial function or cellular stress may not benefit from this research.
What this research studies
This research investigates the role of the endoplasmic reticulum (ER) in producing and managing proteins that are essential for mitochondrial function. It focuses on how certain proteins, particularly phosphatidylserine decarboxylase 1, are processed and degraded within the ER and mitochondria. By examining the relationship between these cellular structures, the research aims to uncover mechanisms that could lead to better understanding of mitochondrial diseases. Patients may benefit from insights gained about how cellular stress affects mitochondrial health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating mitochondrial disorders and improving cellular health.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial biology, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Claypool, Steven Michael — Johns Hopkins University
- Study coordinator: Claypool, Steven Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.