Understanding how the endoplasmic reticulum helps make and manage mitochondrial proteins
Official title: Endoplasmic reticulum-assisted mitochondrial precursor biogenesis and quality control
Funded at Johns Hopkins University · NIH-10899581 · Data updated 2026-11-12
This study looks at how a part of your cells called the endoplasmic reticulum helps make and manage important proteins for your cell's energy factories, the mitochondria, and it aims to find new ways to understand and treat diseases related to cell stress.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 15, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $324,608 |
| NIH project number | 5R01GM151746-02 |
| Project ID | NIH-10899581 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions linked to mitochondrial dysfunction or cellular stress responses.
✕Less likely to help
Patients with unrelated conditions or those not experiencing mitochondrial or cellular stress issues may not benefit from this research.
What this research studies
This research investigates the role of the endoplasmic reticulum (ER) in producing and controlling proteins that are essential for mitochondrial function. It focuses on how certain proteins, particularly phosphatidylserine decarboxylase, are processed and degraded when they are not functioning properly. By examining the relationship between the ER and mitochondria, the research aims to uncover new mechanisms that could lead to better understanding of cellular stress responses and potential treatments for related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases related to mitochondrial dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial biology and its relationship with the endoplasmic reticulum, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Claypool, Steven Michael — Johns Hopkins University
- Study coordinator: Claypool, Steven Michael
Related research
Other NIH-funded projects on the same topics.
-
Targeting hidden brain injuries in iTTP to improve long-term brain health
A researcher aims to find out how silent brain injuries in people with immune thrombotic thrombocytopenic purpura (iTTP) happen, how they affect thinking and stroke risk, and how to prevent them.
-
Accelerated flap coverage for severe leg injuries: earlier reconstruction vs standard timing
This study tests whether doing early flap coverage after a severe leg injury lowers infection risk and improves healing for patients with open wounds and bone injury.
-
Placebo-controlled shunting for iNPH: does the surgery help with walking and balance?
A doctor-led trial at Johns Hopkins will test whether a shunt surgery improves walking and balance in older adults with idiopathic normal pressure hydrocephalus.
-
Omalizumab for COPD patients with allergen sensitization and exposure
A multicenter trial will test whether adding omalizumab helps people with COPD who are allergic to common indoor allergens and are exposed to them.
-
Johns Hopkins Total Worker Health Center focusing on mental health
A nationwide center at Johns Hopkins is working to improve mental health and well-being among workers by studying workplace health strategies and translating findings into practical tools.
-
Role of fat droplets in liver fat and inflammatory signals in NAFLD
A study at Johns Hopkins will explore how fat droplets in the liver influence molecules that drive inflammation and progression of non-alcoholic fatty liver disease (NAFLD) in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.