Understanding how the endoplasmic reticulum helps make and manage mitochondrial proteins
Endoplasmic reticulum-assisted mitochondrial precursor biogenesis and quality control
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-10899581
This study looks at how a part of your cells called the endoplasmic reticulum helps make and manage important proteins for your cell's energy factories, the mitochondria, and it aims to find new ways to understand and treat diseases related to cell stress.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10899581 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the endoplasmic reticulum (ER) in producing and controlling proteins that are essential for mitochondrial function. It focuses on how certain proteins, particularly phosphatidylserine decarboxylase, are processed and degraded when they are not functioning properly. By examining the relationship between the ER and mitochondria, the research aims to uncover new mechanisms that could lead to better understanding of cellular stress responses and potential treatments for related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions linked to mitochondrial dysfunction or cellular stress responses.
Not a fit: Patients with unrelated conditions or those not experiencing mitochondrial or cellular stress issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases related to mitochondrial dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial biology and its relationship with the endoplasmic reticulum, suggesting that this approach could yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CLAYPOOL, STEVEN MICHAEL — JOHNS HOPKINS UNIVERSITY
- Study coordinator: CLAYPOOL, STEVEN MICHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.