Understanding how the endoplasmic reticulum disposes of misfolded proteins and its link to hereditary spastic paraplegias
The connection between ER-phagy, ER structure and hereditary spastic paraplegias
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10846640
This study is looking at how our cells get rid of damaged proteins, especially in people with hereditary spastic paraplegias, to find new ways to help treat neurodegenerative diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10846640 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which the endoplasmic reticulum (ER) disposes of misfolded proteins, particularly focusing on a process called ER-phagy. It aims to understand how specific areas of the ER are targeted for degradation, especially in the context of hereditary spastic paraplegias (HSP). By studying the role of certain proteins and pathways involved in this process, the research seeks to uncover potential therapeutic targets for neurodegenerative diseases linked to protein aggregation. Patients may benefit from insights gained into how to enhance protein disposal mechanisms in their cells.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with hereditary spastic paraplegias or related neurodegenerative disorders.
Not a fit: Patients without hereditary spastic paraplegias or those not affected by neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurodegenerative diseases associated with protein misfolding.
How similar studies have performed: Other research has shown promising results in understanding protein degradation pathways, suggesting that this approach may yield valuable insights.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FERRO-NOVICK, SUSAN — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: FERRO-NOVICK, SUSAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.