Understanding how the endoplasmic reticulum changes with aging in worms
Elucidating the role of ER remodeling in aging of C. elegans
This study is looking at how aging affects a part of our cells called the endoplasmic reticulum, using tiny roundworms to see how these changes might impact overall cell health and could help us find ways to improve health as we get older.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-10909195 on NIH RePORTER |
What this research studies
This research investigates the changes in the endoplasmic reticulum (ER) as it relates to aging, using the model organism C. elegans, a type of roundworm. The study focuses on how the structure of the ER alters with age and how these changes affect cellular functions, particularly in relation to mitochondrial health. By examining the balance between different ER structures and their role in cellular signaling, the research aims to uncover potential therapeutic targets that could slow down age-related diseases. The findings could lead to new strategies for improving health in aging populations by understanding the underlying cellular mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research are older adults experiencing age-related health issues.
Not a fit: Patients with acute conditions unrelated to aging may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down the aging process and reduce age-related diseases.
How similar studies have performed: Other research has shown promising results in understanding cellular aging mechanisms, making this approach a continuation of established scientific inquiry.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Donahue, Eric Kf — Vanderbilt University
- Study coordinator: Donahue, Eric Kf
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.