Understanding how the Drosophila eye develops its top and bottom structures
Official title: Genetic Basis of Dorso-Ventral Patterning in the Drosophila Eye
Funded at University of Dayton · NIH-10887616 · Data updated 2026-11-12
This study looks at how certain genes help shape the top and bottom parts of a fruit fly's eye, which could help us learn more about eye development and related issues in humans.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Dayton NIH-funded |
| Lab location | 1 site (Dayton, United States) |
| Project start | August 1, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $328,525 |
| NIH project number | 5R01EY032959-04 |
| Project ID | NIH-10887616 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with congenital eye defects or developmental abnormalities.
✕Less likely to help
Patients with conditions unrelated to genetic developmental processes may not receive any benefit from this research.
What this research studies
This research investigates the genetic mechanisms that determine the dorso-ventral patterning in the developing eye of the fruit fly, Drosophila melanogaster. By studying how specific genes interact during eye development, the researchers aim to uncover the fundamental processes that lead to the formation of distinct dorsal and ventral compartments. The approach involves analyzing the roles of various transcription factors and morphogens that guide the growth and differentiation of eye tissues. Insights gained from this research could enhance our understanding of similar processes in humans, particularly in relation to congenital defects.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for developmental defects in humans.
How similar studies have gone: While this research explores a well-established area of developmental biology, the specific genetic interactions being studied may yield novel insights that have not been previously tested.
Where this research is happening
-
University of Dayton
Dayton, United States Active
Researchers
- Principal investigator: Singh, Amit — University of Dayton
- Study coordinator: Singh, Amit
Related research
Other NIH-funded projects on the same topics.
-
Computer help to spot lung nodules on children's CT scans
This project will build a computer tool to help doctors find lung nodules on chest CT scans for children and young adults.
-
Detecting lung nodules in children's CT scans using advanced technology
This study is working on a smart computer program that helps doctors find tiny lumps in kids' lungs on CT scans, making it easier to catch any signs of cancer early and improve treatment for young patients.
-
Advanced 3D imaging technology for observing nanoscale biological structures
This study is exploring a new 3D imaging tool that helps scientists see tiny biological structures more clearly, which could lead to better ways to diagnose and treat diseases that affect you.
-
Understanding how a brain structure affects attention and behavior
This study is looking at a part of the brain that helps with how we process senses, pay attention, and sleep, to see how a specific protein affects its function, which could help us understand and improve treatments for conditions like autism and ADHD.
-
Creating assistive devices for individuals with disabilities through collaboration
This study is all about creating helpful devices for kids and adults with disabilities, so they can do everyday tasks more easily and enjoy life in their communities, with occupational therapists and engineers working together to make sure these devices fit each person's unique needs.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.