Understanding how the DREAM complex helps prevent lung tumors
Official title: Role of the DREAM complex in the lung tumor suppression
Funded at Virginia Commonwealth University · NIH-10775737 · Data updated 2026-11-12
This study is looking at how a specific protein complex helps stop lung tumors from forming, especially in people with non-small cell lung cancer who have been exposed to harmful substances like tobacco smoke, with the hope of finding new ways to prevent or treat lung cancer.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project start | February 3, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $172,376 |
| NIH project number | 5R21CA277518-02 |
| Project ID | NIH-10775737 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at high risk for lung cancer, such as heavy smokers or those with a history of significant exposure to lung carcinogens.
✕Less likely to help
Patients with lung cancer who are already in advanced stages of the disease may not benefit from this research.
What this research studies
This research investigates the role of a protein complex known as DREAM in suppressing lung tumors, particularly focusing on non-small cell lung cancer (NSCLC). The study aims to uncover the molecular mechanisms that prevent damaged airway cells from progressing to cancer, especially in individuals with significant exposure to carcinogens like tobacco smoke. By utilizing genetically engineered mouse models, the research seeks to develop accurate representations of early lung cancer stages and identify potential therapeutic targets. Patients may benefit from insights that could lead to new prevention strategies or treatments for lung cancer.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating lung cancer, potentially saving lives.
How similar studies have gone: Previous studies have shown success in understanding tumor suppression mechanisms, but the specific role of the DREAM complex in lung cancer is still being explored.
Where this research is happening
-
Virginia Commonwealth University
Richmond, United States Active
Researchers
- Principal investigator: Litovchick, Larisa — Virginia Commonwealth University
- Study coordinator: Litovchick, Larisa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.