Understanding how the DREAM complex helps prevent lung tumors
Role of the DREAM complex in the lung tumor suppression
['FUNDING_R21'] · VIRGINIA COMMONWEALTH UNIVERSITY · NIH-10775737
This study is looking at how a specific protein complex helps stop lung tumors from forming, especially in people with non-small cell lung cancer who have been exposed to harmful substances like tobacco smoke, with the hope of finding new ways to prevent or treat lung cancer.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA COMMONWEALTH UNIVERSITY (nih funded) |
| Locations | 1 site (RICHMOND, UNITED STATES) |
| Trial ID | NIH-10775737 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein complex known as DREAM in suppressing lung tumors, particularly focusing on non-small cell lung cancer (NSCLC). The study aims to uncover the molecular mechanisms that prevent damaged airway cells from progressing to cancer, especially in individuals with significant exposure to carcinogens like tobacco smoke. By utilizing genetically engineered mouse models, the research seeks to develop accurate representations of early lung cancer stages and identify potential therapeutic targets. Patients may benefit from insights that could lead to new prevention strategies or treatments for lung cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at high risk for lung cancer, such as heavy smokers or those with a history of significant exposure to lung carcinogens.
Not a fit: Patients with lung cancer who are already in advanced stages of the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating lung cancer, potentially saving lives.
How similar studies have performed: Previous studies have shown success in understanding tumor suppression mechanisms, but the specific role of the DREAM complex in lung cancer is still being explored.
Where this research is happening
RICHMOND, UNITED STATES
- VIRGINIA COMMONWEALTH UNIVERSITY — RICHMOND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LITOVCHICK, LARISA — VIRGINIA COMMONWEALTH UNIVERSITY
- Study coordinator: LITOVCHICK, LARISA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer, NSCLC - Non-Small Cell Lung Cancer, Non-Small Cell Lung Cancer