Understanding how the COVID-19 virus enters human cells
Real-time structural and functional studies of SARS-CoV-2 spike proteins
This research looks closely at how the SARS-CoV-2 virus uses its spike protein to get into our cells, hoping to find new ways to stop it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project ID | NIH-11136856 on NIH RePORTER |
What this research studies
Our bodies have a protein called ACE2 that the COVID-19 virus uses like a key to unlock our cells and cause infection. This project uses advanced imaging to watch in real-time how the virus's spike protein connects with ACE2 and how this interaction leads to the virus entering the cell. By understanding these movements, we can learn more about how the virus works. This detailed view could help us find new targets for medicines or vaccines.
Who could benefit from this research
Good fit: This foundational laboratory research does not directly involve patient participation, but it is relevant to anyone affected by COVID-19.
Not a fit: Patients not affected by COVID-19 or related coronavirus infections would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to the development of more effective diagnostic tools and treatments, including new antibodies or drugs, for COVID-19.
How similar studies have performed: While static images of the spike protein exist, this project uses novel real-time imaging techniques to capture the dynamic interactions, offering a new perspective.
Where this research is happening
Austin, United States
- University of Texas at Austin — Austin, United States (Active)
Researchers
- Principal investigator: Lin, Yi-Chih — University of Texas at Austin
- Study coordinator: Lin, Yi-Chih
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.