Understanding how the coronal suture in the skull develops and what happens when it doesn't
Coronal Suture Development in Health and Disease
This study looks at how a key part of the skull develops in babies and what happens when it grows incorrectly, which can cause problems like craniosynostosis; by studying mice, researchers hope to find ways to improve treatments for kids with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10884435 on NIH RePORTER |
What this research studies
This research investigates the development of the coronal suture, a critical area in the skull that can lead to conditions like craniosynostosis when it fuses prematurely. The study focuses on the migration and behavior of specific cell populations during early embryonic stages and how their misregulation can result in health issues. By analyzing these processes in mice, researchers aim to identify the genetic and cellular factors involved in normal and abnormal suture development. This knowledge could lead to better treatment strategies for patients affected by craniosynostosis and related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with craniosynostosis, particularly those with syndromic forms like Apert syndrome or Chotzen syndrome.
Not a fit: Patients with non-syndromic craniosynostosis or those without any cranial development disorders may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could provide insights that lead to improved treatments for craniosynostosis and enhance our understanding of skull development disorders.
How similar studies have performed: Previous research has shown promising results in understanding craniosynostosis through genetic and cellular studies, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Holmes, Greg Peter — Icahn School of Medicine at Mount Sinai
- Study coordinator: Holmes, Greg Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.