Understanding how the cornea develops its shape
Mechanisms of development of curved refractive surfaces
This study is looking at how the shape of the cornea, which is important for clear vision, develops in fruit flies to help us understand similar processes in humans, with the hope of finding better ways to treat vision problems like astigmatism and keratoconus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10850920 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the development of the cornea's curvature, which is crucial for proper vision. Using the Drosophila corneal lens as a model, the study aims to uncover the molecular processes that contribute to corneal shape and how these may relate to similar processes in humans. By examining specific genes and transcription factors involved in this development, the research seeks to identify potential targets for improving treatments for visual defects like astigmatism and keratoconus.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing visual defects such as astigmatism, myopia, or keratoconus.
Not a fit: Patients with normal corneal curvature or those not affected by visual defects may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for common vision problems related to corneal curvature.
How similar studies have performed: While the approach of using Drosophila as a model for corneal development is established, the specific mechanisms being investigated may offer novel insights into human corneal conditions.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Treisman, Jessica E — New York University School of Medicine
- Study coordinator: Treisman, Jessica E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.