Understanding how the cGAS-STING pathway regulates immune responses
Regulation of immunity by the cGAS-STING pathway
['FUNDING_R01'] · BOSTON CHILDREN'S HOSPITAL · NIH-10886044
This study is looking at how a specific enzyme helps the immune system recognize DNA from tumors and how this process can both fight cancer and sometimes help it grow, with the goal of finding better ways to use the immune system to treat cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10886044 on ClinicalTrials.gov |
What this research studies
This research investigates how the enzyme cGAS detects self-DNA and its role in regulating inflammation within tumors. By studying the cGAS-STING pathway, the research aims to understand how this pathway can both promote immune responses against tumors and potentially contribute to tumor growth. The approach involves examining the signaling activities of cGAS and their effects on immune cells, particularly CD8+ T cells, in the tumor microenvironment. This could lead to insights into how to better harness the immune system for cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers that may benefit from enhanced immune responses.
Not a fit: Patients with non-cancerous conditions or those whose tumors do not involve the cGAS-STING pathway may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer therapies that effectively utilize the immune system to fight tumors.
How similar studies have performed: Previous research has shown promising results in targeting the cGAS-STING pathway for cancer treatment, indicating potential for success in this area.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KAGAN, JONATHAN C — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: KAGAN, JONATHAN C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers