Understanding how the cerebellum controls movement precision
Official title: Functional roles of inhibitory cerebellar outputs
Funded at University of Colorado Denver · NIH-10990180 · Data updated 2026-11-12
This study is looking at how certain brain cells in the cerebellum help us move accurately, and it hopes to find ways to improve movement for people with conditions like cerebellar ataxia and dysmetria.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 4, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $503,439 |
| NIH project number | 1R37NS131839-01A1 |
| Project ID | NIH-10990180 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with cerebellar ataxia or other cerebellar disorders affecting movement precision.
✕Less likely to help
Patients with non-cerebellar movement disorders or those without significant motor control issues may not benefit from this research.
What this research studies
This research investigates the role of specific neurons in the cerebellum that help regulate the accuracy of movements. By studying how these neurons communicate and adapt during reaching tasks, the research aims to uncover mechanisms that could improve motor control in individuals with cerebellar disorders. The approach involves manipulating neural circuits in a controlled environment to observe changes in movement patterns. Patients may benefit from insights that could lead to new therapies for conditions like cerebellar ataxia and dysmetria.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with movement disorders caused by cerebellar dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding cerebellar function and its impact on movement, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Person, Abigail L — University of Colorado Denver
- Study coordinator: Person, Abigail L
Related research
Other NIH-funded projects on the same topics.
-
Understanding how alcohol and how couples talk about consent affect intimate partner sexual violence
This project studies how alcohol use and how partners communicate about consent influence intimate partner sexual violence among sexual minority and heterosexual couples.
-
How proteins change and move as heart cells develop
This grant aims to map how protein turnover changes as human iPSCs turn into cardiomyocytes and other cell types, using new labeling and mass-spectrometry methods.
-
Center for Health, Work and Environment
A national center dedicated to improving health in people who work, by studying how jobs affect well-being and safety.
-
Subtyping Core for Research on the Causes of Type 2 Diabetes (SCORE-T2D)
A new U01 grant from a university research team aims to understand why Type 2 diabetes differs so much between people and how to tailor prevention and treatment.
-
Expanded antibody-based clues to TB risk in people with HIV
A clinician-scientist seeks to understand how antibodies in people with HIV may drive the progression from latent TB to active TB, with the goal of identifying clues that could guide future care.
-
Human Trisome Project in Latin America Network
A large, multi-site study of people with Down syndrome across Latin America to better understand health and aging in DS.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.