Understanding how the cerebellum controls movement coordination
The role of cerebellar output in the control of motor coordination
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF COLORADO DENVER · NIH-11014408
This study is looking at how a part of the brain called the anterior interposed nucleus helps us make precise movements with our arms and legs, using mice to learn more about how our brains coordinate these actions.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-11014408 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific part of the cerebellum, known as the anterior interposed nucleus (IntA), in controlling precise limb movements. By studying how IntA neurons fire during complex motor tasks, the research aims to uncover how these signals contribute to coordinated movements. The approach includes using advanced techniques like in vivo recordings and optogenetic manipulations in mice to explore how the brain ensures accuracy in reaching for targets. This could lead to a better understanding of motor control and learning.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing motor coordination deficits related to cerebellar dysfunction.
Not a fit: Patients without cerebellar damage or those with other unrelated motor conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could improve treatments for individuals with motor coordination issues due to cerebellar damage.
How similar studies have performed: Previous research has shown promising results in understanding cerebellar function and its impact on motor control, indicating that this approach has potential for success.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DOBROTT, COURTNEY I — UNIVERSITY OF COLORADO DENVER
- Study coordinator: DOBROTT, COURTNEY I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.