Understanding how the central amygdala affects withdrawal from oxycodone
Official title: Functional and molecular characterization of the central amygdala in the context of oxycodone withdrawal
Funded at Washington University · NIH-11053470 · Data updated 2026-11-12
This study looks at how a part of the brain called the central amygdala affects people trying to stop using oxycodone, an opioid, by exploring how certain brain cells behave during withdrawal, which could help improve treatment for those dealing with opioid dependence.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $165,911 |
| NIH project number | 5K99DA056691-02 |
| Project ID | NIH-11053470 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced withdrawal symptoms from oxycodone or other opioids.
✕Less likely to help
Patients who have never used opioids or those who are not experiencing withdrawal symptoms may not benefit from this research.
What this research studies
This research investigates the role of the central amygdala in the withdrawal process from oxycodone, a commonly prescribed opioid. By examining specific neuronal subpopulations within this brain region, the study aims to identify how these cells contribute to withdrawal symptoms and the potential for relapse into drug use. The approach includes using rodent models to observe changes in behavior and neuronal activity during withdrawal. This research could lead to better treatment strategies for individuals struggling with opioid dependence.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for managing opioid withdrawal and reducing the risk of relapse.
How similar studies have gone: Previous research has shown that targeting specific brain regions can influence withdrawal behaviors, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Slivicki, Richard — Washington University
- Study coordinator: Slivicki, Richard
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.