Understanding how the central amygdala affects neuropathic pain
Official title: The integration of laboratory data with computational 3-D modeling to analyze the role of the central amygdala in neuropathic pain
Funded at Duquesne University · NIH-10650977 · Data updated 2026-11-12
This study is looking at how a part of the brain called the central amygdala affects nerve pain, with the goal of finding new ways to help people who suffer from this type of pain.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duquesne University NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 7, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $441,500 |
| NIH project number | 1R15NS128624-01A1 |
| Project ID | NIH-10650977 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from neuropathic pain, particularly those with a history of nerve injury.
✕Less likely to help
Patients with acute pain conditions unrelated to nerve injury may not benefit from this research.
What this research studies
This research investigates the role of the central amygdala in neuropathic pain, which affects many individuals globally. By integrating laboratory data with advanced computational 3-D modeling, the study aims to analyze how changes in the amygdala contribute to pain perception following nerve injury. The approach utilizes cutting-edge techniques such as optogenetics and chemogenetics to gather detailed cellular data, which is then modeled to better understand the interactions between different cell types involved in pain. This comprehensive analysis could lead to new therapeutic strategies for managing neuropathic pain.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for neuropathic pain, improving the quality of life for many patients.
How similar studies have gone: Previous research has shown promise in understanding pain mechanisms through similar integrative approaches, suggesting potential for success in this novel application.
Where this research is happening
-
Duquesne University
Pittsburgh, United States Active
Researchers
- Principal investigator: Miller Neilan, Rachael — Duquesne University
- Study coordinator: Miller Neilan, Rachael
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.