Understanding how the cell cycle is controlled to improve cancer therapies
Official title: Molecular Mechanisms of Cell Cycle Dependent Gene Expression
Funded at University of California Santa Cruz · NIH-11376901 · Data updated 2026-11-12
A cancer-focused grant researching the molecular switches that tell cells when to divide, with goals that could lead to better cancer medicines.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Cruz NIH-funded |
| Lab location | 1 site (Santa Cruz, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $572,421 |
| NIH project number | 5R35GM145255-05 |
| Project ID | NIH-11376901 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable at this stage; the grant is basic research building blocks that may inform future patient-focused studies.
✕Less likely to help
Direct patient benefit is not immediate; results may take time to translate into therapies.
What this research studies
This project looks at the proteins and pathways that control when a cell decides to grow and divide, using ideas from structural biology and cell-based experiments. By studying transcription factors and the enzymes that modify them, researchers aim to uncover new details about how gene expression is tied to the cell cycle. The work combines physical mapping of protein interactions with tests in cells to see how these processes affect chromatin and transcription. The findings could reveal new targets to refine cancer treatments and overcome current drug limitations.
Why it matters
Potential benefit: If successful, the research could identify new targets and strategies for more effective cancer therapies.
How similar studies have gone: Previous work has shown that cell-cycle control proteins influence cancer progression and therapy response, with ongoing research building on these concepts.
Where this research is happening
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University of California Santa Cruz
Santa Cruz, United States Active
Researchers
- Principal investigator: Rubin, Seth Michael — University of California Santa Cruz
- Study coordinator: Rubin, Seth Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.