Understanding how the calcium sensing receptor regulates calcium metabolism
Mechanistic Basis of Calcium Sensing Receptor Signaling
This study is looking at how a special receptor in your body helps control calcium levels, and it's trying to find new ways to improve treatments for people with chronic kidney disease who have issues with their parathyroid glands.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11072971 on NIH RePORTER |
What this research studies
This research investigates the calcium sensing receptor (CaSR), which plays a crucial role in regulating calcium levels in the body. The team aims to explore the mechanisms by which CaSR is activated and how it interacts with small-molecule drugs that can enhance its function. By using advanced techniques like cryo-electron microscopy, they will analyze the structure of CaSR in both active and inactive states. The goal is to develop better therapeutic options for patients with chronic kidney disease who suffer from parathyroid disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old with chronic kidney disease and associated parathyroid disorders.
Not a fit: Patients without chronic kidney disease or those who do not have parathyroid disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with chronic kidney disease and related parathyroid disorders, reducing side effects associated with current medications.
How similar studies have performed: Previous research has shown promise in targeting the calcium sensing receptor for therapeutic purposes, indicating a potential for success in this area.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Skiniotis, Georgios — St. Jude Children's Research Hospital
- Study coordinator: Skiniotis, Georgios
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.