Understanding how the BRCA network helps prevent cancer by studying DNA repair mechanisms.
Core 2: Genomics
This study is looking at how certain genes help fix DNA damage, which could lead to new ways to prevent and treat cancer, and it's designed for patients who want to learn more about their genetic health.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11080272 on NIH RePORTER |
What this research studies
This research focuses on the Genomics Core, which provides advanced genomic profiling and bioinformatics analysis to support projects aimed at understanding the BRCA network's role in DNA damage repair and maintaining genomic integrity. Patients may benefit from insights gained through techniques like whole genome sequencing and ATAC-seq, which analyze how genes are regulated in response to DNA damage. The research aims to identify genomic alterations that could lead to better cancer prevention and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of breast or ovarian cancer or those who carry BRCA mutations.
Not a fit: Patients without a genetic predisposition to BRCA-related cancers or those not interested in genomic profiling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients at risk of cancer due to BRCA-related genomic instability.
How similar studies have performed: Previous research has shown success in using genomic profiling to understand cancer mechanisms, indicating that this approach is both promising and well-established.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: De, Subhajyoti — Rutgers Biomedical and Health Sciences
- Study coordinator: De, Subhajyoti
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.