Understanding how the brain's waste clearance system affects chronic pain and sleep.
The glymphatic system at the crossroad of integrative health approaches inchronic pain
['FUNDING_R01'] · UNIVERSITY OF ROCHESTER · NIH-11083083
This study is looking at how chronic pain affects the brain's waste-clearing system and sleep, using mice to see if common pain treatments can help improve both pain and sleep quality, which could lead to better options for people dealing with these issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11083083 on ClinicalTrials.gov |
What this research studies
This research investigates the glymphatic system, which helps clear waste from the brain, and its relationship with chronic pain and sleep disturbances. By using a mouse model of neuropathic pain, the study aims to explore how chronic pain affects glymphatic function and how traditional pain relief methods might improve both pain and sleep quality. The researchers will examine the role of norepinephrine, a stress-related chemical, in disrupting sleep and glymphatic function. The findings could provide insights into new treatment approaches for patients suffering from chronic pain and sleep issues.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing chronic pain, particularly those with sleep disturbances.
Not a fit: Patients who do not suffer from chronic pain or related sleep issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved pain management strategies and better sleep quality for patients with chronic pain conditions.
How similar studies have performed: Previous research has shown that enhancing glymphatic function can improve outcomes in models of chronic pain, suggesting a promising avenue for further exploration.
Where this research is happening
ROCHESTER, UNITED STATES
- UNIVERSITY OF ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NEDERGAARD, MAIKEN — UNIVERSITY OF ROCHESTER
- Study coordinator: NEDERGAARD, MAIKEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.