Understanding how the brain's immune system can attack itself
Molecular understanding of self immunity in the brain
This study is looking into how the immune system mistakenly attacks the brain in certain neurological disorders, aiming to find out what triggers these reactions so that we can better understand and treat patients who are affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10619124 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind autoimmune responses in the brain, particularly focusing on paraneoplastic neurological disorders (PNDs). It utilizes advanced techniques like programmable phage display to identify specific antigens that trigger these autoimmune reactions. By characterizing these antigens and their role in causing symptoms, the research aims to improve understanding of how the immune system interacts with the nervous system. The study also explores new pathways of immune response that could lead to innovative treatment strategies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with paraneoplastic neurological disorders and related autoimmune conditions.
Not a fit: Patients with neurological disorders not related to autoimmune responses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and targeted therapies for patients suffering from autoimmune neurological disorders.
How similar studies have performed: Other research in neuro-immunology has shown promise in understanding autoimmune conditions, suggesting that this approach could yield significant insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Mandel-Brehm, Caleigh — Yale University
- Study coordinator: Mandel-Brehm, Caleigh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.