Understanding how the brain's genome structure affects development and behavior
Mechanisms of Genome Organization in Brain Development and Behavior
['FUNDING_U01'] · NORTHWESTERN UNIVERSITY · NIH-10911240
This study looks at how the way our genes are arranged in 3D affects how brain cells connect with each other, especially in young mice, and it aims to understand how experiences and signals during development can change this gene arrangement to influence brain function and behavior.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-10911240 on ClinicalTrials.gov |
What this research studies
This research investigates how the three-dimensional organization of the genome influences neuronal connectivity in the brain, particularly during development. It explores how sensory experiences and developmental signals can reshape the genome architecture in living organisms, focusing on the cerebellum in mice. By examining long-distance interactions between genes critical for brain function, the study aims to uncover the biological mechanisms that govern brain wiring and connectivity. The research employs advanced techniques to analyze genome interactions and their implications for brain development and behavior.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autism spectrum disorder (ASD) or related developmental conditions.
Not a fit: Patients with neurological conditions unrelated to genetic factors or those without developmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic factors influencing brain development and behavior, potentially informing treatments for conditions like autism.
How similar studies have performed: Previous research has shown promising results in understanding genome architecture's role in brain function, suggesting that this approach could yield valuable insights.
Where this research is happening
Chicago, UNITED STATES
- NORTHWESTERN UNIVERSITY — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YAMADA, TOMOKO — NORTHWESTERN UNIVERSITY
- Study coordinator: YAMADA, TOMOKO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autistic Disorder