Understanding how the brain's extracellular matrix affects behavior and plasticity
Revealing the extensive structural features and regulatory process of the brain’s ECM
This study is looking at a special part of the brain called the extracellular matrix, which helps brain cells work properly, and it's using a new tool to see how this matrix changes and interacts with different brain cells, hoping to learn more about how our brains function and what might go wrong in certain conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10952153 on NIH RePORTER |
What this research studies
This research investigates the brain's extracellular matrix (ECM), which is crucial for various brain functions, including neuronal plasticity and behavior. Using a novel live-cell probe called H-Link, the study aims to visualize and understand how the ECM is structured and regulated in real-time. By examining how different types of neurons interact with the ECM, the research seeks to uncover the mechanisms behind its organization and remodeling, which could lead to insights into brain function and dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing age-related cognitive decline or neurological conditions that affect behavior and plasticity.
Not a fit: Patients with acute neurological injuries or those not experiencing any cognitive or behavioral issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain function and lead to new treatments for neurological disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of the ECM in other tissues, suggesting potential success in this novel approach for brain ECM.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Park, Sung Jin — University of Utah
- Study coordinator: Park, Sung Jin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.