Understanding how the brain transfers memories for long-term storage
Official title: Brain dynamics underlying long-term memory consolidation
Funded at Rockefeller University · NIH-10658311 · Data updated 2026-11-12
This study is looking at how our brains move memories from short-term storage to long-term storage, which is especially important for people with conditions like Alzheimer's or PTSD, and it uses mice to help figure out how this process works so we can find better ways to help with memory problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,220,400 |
| NIH project number | 1RF1NS132047-01 |
| Project ID | NIH-10658311 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing memory issues related to Alzheimer's disease or other forms of dementia.
✕Less likely to help
Patients with memory issues not related to the mechanisms being studied, such as those with purely psychological causes, may not benefit from this research.
What this research studies
This research investigates the brain mechanisms involved in transferring memories from the hippocampus to long-term storage in the cortex. It focuses on understanding how memories can become either too fleeting, as seen in conditions like Alzheimer's disease, or overly persistent, as in PTSD. The study employs advanced imaging techniques and behavioral models in mice to track neural activity over time, aiming to identify the specific brain pathways involved in memory consolidation. By dissecting these processes, the research hopes to provide insights into memory regulation and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing memory retention and addressing memory-related disorders.
How similar studies have gone: Previous research has shown promising results in understanding memory consolidation mechanisms, but this specific approach is relatively novel.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Rajasethupathy, Priya — Rockefeller University
- Study coordinator: Rajasethupathy, Priya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.