Understanding how the brain retrieves memories in Alzheimer's disease
Neural Mechanism for Successful Memory Access in the Cortico-Hippocampal Networks
This study is looking at how the brain helps us remember things, especially in people with Alzheimer's disease, to find better ways to understand and diagnose memory problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10814776 on NIH RePORTER |
What this research studies
This research investigates the neural mechanisms involved in memory retrieval, particularly focusing on the hippocampal-entorhinal circuits that are crucial for forming and accessing memories. By studying these brain circuits during specific memory tasks, the research aims to uncover how memories are accessed and utilized in individuals with Alzheimer's disease and related conditions. The approach includes in vivo recordings from animal models to inform potential diagnostic measures for human patients. Ultimately, the goal is to enhance our understanding of memory deficits associated with Alzheimer's and improve diagnostic techniques.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias who experience memory deficits.
Not a fit: Patients with memory issues not related to Alzheimer's disease or those without cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and therapeutic strategies for patients suffering from memory-related conditions like Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding memory mechanisms in animal models, suggesting potential for success in human applications.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Yamamoto, Jun — Ut Southwestern Medical Center
- Study coordinator: Yamamoto, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.