Understanding how the brain responds to stress and cravings in people with opioid addiction
Plasticity of Aversive Salience in Opioid Use Disorder
['FUNDING_R01'] · LAUREATE INSTITUTE FOR BRAIN RESEARCH · NIH-11003735
This study is looking at how the brain works during recovery from opioid addiction, especially how it reacts to cravings and stress, to help create better treatment plans for people trying to overcome this challenge.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LAUREATE INSTITUTE FOR BRAIN RESEARCH (nih funded) |
| Locations | 1 site (TULSA, UNITED STATES) |
| Trial ID | NIH-11003735 on ClinicalTrials.gov |
What this research studies
This research investigates the brain mechanisms that affect recovery from opioid use disorder, focusing on how the brain responds to both internal signals (like cravings and withdrawal) and external stressors. By studying brain circuitry related to aversive stimuli, the research aims to identify factors that either hinder or promote recovery in individuals seeking treatment for opioid addiction. The study will involve comparing brain responses in treatment-seeking individuals with opioid use disorder to those of healthy controls, with the goal of developing personalized treatment strategies to reduce relapse rates and improve recovery outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals seeking treatment for opioid use disorder.
Not a fit: Patients who are not seeking treatment for opioid use disorder or those with other substance use disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, individualized treatments for opioid addiction, potentially reducing relapse rates and improving recovery outcomes.
How similar studies have performed: Other research has shown promise in understanding brain mechanisms related to addiction, but this specific approach focusing on aversive salience in opioid use disorder is relatively novel.
Where this research is happening
TULSA, UNITED STATES
- LAUREATE INSTITUTE FOR BRAIN RESEARCH — TULSA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STEWART, JENNIFER LORRAINE — LAUREATE INSTITUTE FOR BRAIN RESEARCH
- Study coordinator: STEWART, JENNIFER LORRAINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: addictive disorder