Understanding how the brain represents feelings of loneliness and connection to others

Using the Brain to Reveal Mental Representations of Subjective Connection

NIH-funded research Columbia Univ New York Morningside · NIH-11034058

This study is looking at how feeling lonely changes the way our brains think about our relationships with others, and it's for anyone who wants to understand more about loneliness and how to feel more connected.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionColumbia Univ New York Morningside NIH-funded
Lab location1 site (New York, United States)
Project IDNIH-11034058 on NIH RePORTER

What this research studies

This research investigates how loneliness affects the brain's representation of our connections to others. By using functional MRI (fMRI), participants will engage in tasks that explore their feelings of closeness and familiarity with different individuals. The study aims to identify specific brain regions involved in these processes, particularly the medial prefrontal cortex and posterior cingulate, and how loneliness alters these mental representations. The ultimate goal is to find new ways to reduce feelings of loneliness through targeted interventions.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals who experience feelings of loneliness or subjective isolation.

Not a fit: Patients who do not experience loneliness or have no interest in understanding their social connections may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to innovative strategies for alleviating loneliness and improving mental health.

How similar studies have performed: Previous research has shown promising results in understanding the neurobiological aspects of loneliness, suggesting that this approach could yield valuable insights.

Where this research is happening

New York, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.