Understanding how the brain repairs damaged myelin
Glial Mechanisms Governing the Removal and Repair of Degenerating Myelin
This study is looking at how the brain repairs its protective covering around nerve fibers, which can get damaged in conditions like multiple sclerosis, to help find better ways to support recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-10914157 on NIH RePORTER |
What this research studies
This research investigates the processes involved in the removal and repair of myelin, a protective sheath around nerve fibers in the brain that can degenerate in various diseases. By using advanced imaging techniques and manipulating specific cell types in live animals, the study aims to uncover the cellular dynamics and molecular mechanisms that govern myelin repair. The research focuses on understanding how certain brain cells, particularly phagocytic cells, contribute to the efficient removal of damaged myelin, which is crucial for recovery from conditions like multiple sclerosis and age-related degeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from conditions that involve myelin degeneration, such as multiple sclerosis or age-related cognitive decline.
Not a fit: Patients with conditions unrelated to myelin degeneration or those who are not experiencing cognitive or motor impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for enhancing myelin repair and improving outcomes for patients with neurodegenerative diseases.
How similar studies have performed: Other research has shown promise in understanding myelin repair mechanisms, but this study employs novel techniques that may provide new insights into the process.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Hill, Robert — Dartmouth College
- Study coordinator: Hill, Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.