Understanding how the brain regulates chronic pain
Molecular Mechanism of Brain Regulation of Chronic Pain
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-10812420
This study is looking at how a part of the brain affects the way we feel chronic pain, using mice to learn more about specific channels that might change short-term pain into long-lasting pain, with the hope of finding better treatments for people dealing with chronic pain.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10812420 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which the brain, specifically the anterior cingulate cortex, influences the perception of chronic pain. By using mouse models, the study examines how certain ion channels, particularly ASIC1a, contribute to the transition from acute to chronic pain. The goal is to uncover new insights that could lead to more effective treatments for chronic pain, moving beyond current therapies that often have significant side effects. Patients may benefit from a deeper understanding of their pain and potential new therapeutic options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic pain conditions, particularly those who have not found relief with standard pain management therapies.
Not a fit: Patients with acute pain or those whose pain is not related to chronic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for chronic pain that are more effective and have fewer side effects than current options.
How similar studies have performed: Previous research has shown promise in understanding pain mechanisms, but this specific focus on ASIC1a in the brain's pain processing centers is relatively novel.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHU, MICHAEL X — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: ZHU, MICHAEL X
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.