Understanding how the brain processes spoken language in people with aphasia after a stroke

Reliability and validity of temporal response function modeling in aphasia

NIH-funded research University of Houston · NIH-10991805

This study is looking at how people with stroke-related language difficulties understand spoken words by measuring their brain activity, and it aims to create a new way to better understand their listening skills without needing them to answer questions.

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionUniversity of Houston NIH-funded
Lab location1 site (Houston, United States)
Project IDNIH-10991805 on NIH RePORTER

What this research studies

This research investigates how individuals with stroke-induced aphasia comprehend spoken language by analyzing their brain responses to continuous speech using electroencephalography (EEG). The study aims to develop a new method, called temporal response function modeling, which allows researchers to objectively assess auditory comprehension without requiring participants to respond overtly. By examining the neural correlates of auditory comprehension, the research seeks to identify specific deficits and improve clinical assessments and treatments for aphasia. This approach is designed to provide a more accurate understanding of language processing in everyday communication contexts.

Who could benefit from this research

Good fit: Ideal candidates for this research are adults who have experienced a stroke and are currently facing challenges with auditory comprehension due to aphasia.

Not a fit: Patients who do not have aphasia or have not experienced a stroke may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to better diagnostic tools and treatment strategies for individuals with aphasia, ultimately improving their communication abilities and quality of life.

How similar studies have performed: Previous research has shown promise in using EEG and similar modeling techniques to assess language processing, indicating that this approach may yield valuable insights.

Where this research is happening

Houston, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.