Understanding how the brain processes spatial information in Alzheimer's and epilepsy
Official title: Convergence of top-down and bottom-up thalamic inputs in medial entorhinal cortex
Funded at Stanford University · NIH-10946969 · Data updated 2026-11-12
This study is looking at how certain parts of the brain help with learning and memory in people with Temporal Lobe Epilepsy and Alzheimer's Disease, to find out how changes in the brain might affect thinking and memory, which could help in developing new treatments.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $73,828 |
| NIH project number | 1F32NS138225-01 |
| Project ID | NIH-10946969 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's Disease or Temporal Lobe Epilepsy who experience significant memory and navigation difficulties.
✕Less likely to help
Patients with cognitive impairments not related to Alzheimer's Disease or Temporal Lobe Epilepsy may not benefit from this research.
What this research studies
This research investigates how the medial entorhinal cortex (MEC) and hippocampus in the brain contribute to learning and memory, particularly in patients with Temporal Lobe Epilepsy (TLE) and Alzheimer's Disease (AD). By utilizing advanced techniques such as high-density electrophysiological recordings and 3D video analysis, the study aims to uncover how the brain updates spatial maps to adapt to changing environments and behaviors. This understanding could lead to identifying specific vulnerabilities in the brain's circuitry that contribute to cognitive impairments, potentially guiding future therapeutic interventions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for alleviating cognitive impairments in patients with Alzheimer's Disease and Temporal Lobe Epilepsy.
How similar studies have gone: Previous research has shown promising results in understanding brain function related to memory and navigation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Cho, Frances — Stanford University
- Study coordinator: Cho, Frances
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.