Understanding how the brain processes nerve damage from chemotherapy
Assessing the role of the interoceptive brain system in the pathophysiology and treatment of chemotherapy-induced peripheral neuropathy
This study is looking at how chemotherapy can cause nerve damage and affect the way your brain feels and responds to that damage, with the hope of finding better treatments for people dealing with these side effects.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10288334 on NIH RePORTER |
What this research studies
This research investigates the impact of chemotherapy-induced peripheral neuropathy (CIPN) on patients, focusing on how the brain's interoceptive system responds to nerve damage caused by chemotherapy. By using advanced brain imaging techniques like fMRI, the study aims to uncover the underlying mechanisms of CIPN and explore potential new treatments. The research involves a clinical trial with 66 patients who have experienced CIPN, assessing their brain connectivity and symptoms to better understand this condition. The ultimate goal is to develop targeted therapies that can alleviate the debilitating effects of CIPN.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have developed peripheral neuropathy as a result of neurotoxic chemotherapy.
Not a fit: Patients who have not undergone neurotoxic chemotherapy or do not experience symptoms of peripheral neuropathy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, effective treatments for patients suffering from chemotherapy-induced peripheral neuropathy.
How similar studies have performed: Previous research has shown promising results in understanding brain-mediated conditions, suggesting that this innovative approach could yield valuable insights into CIPN.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Lin, Po-Ju — University of Rochester
- Study coordinator: Lin, Po-Ju
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.