Understanding how the brain processes complex sounds for clear hearing

Neural bases of masked amplitude-modulation perception

NIH-funded research University of Rochester · NIH-11131103

This research explores how our brains separate different sounds, like speech from background noise, to help people hear better in challenging environments.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Rochester NIH-funded
Lab location1 site (Rochester, United States)
Project IDNIH-11131103 on NIH RePORTER

What this research studies

Our ability to understand speech relies on how our brains process subtle changes in sound, called amplitude modulation. Sometimes, when many sounds are present, our brains struggle to pick out the important ones, a problem known as modulation masking. This project uses behavioral and brain activity experiments in budgerigars, a type of parakeet known for its human-like hearing, to understand how the brain's 'modulation filterbank' works. By studying how these birds process complex sounds, we hope to uncover the basic mechanisms that allow us to hear clearly, even when there's a lot of background noise.

Who could benefit from this research

Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals who struggle with hearing speech in noisy environments in the future.

Not a fit: Patients seeking immediate treatment or direct clinical intervention would not receive direct benefit from this basic science project.

Why it matters

Potential benefit: If successful, this work could lead to new ways to help people with hearing difficulties better understand speech in noisy situations.

How similar studies have performed: The concept of a 'modulation filterbank' is an exciting theoretical advancement that explains human hearing phenomena, but its physiological mechanisms are still poorly understood.

Where this research is happening

Rochester, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.