Understanding how the brain processes avoidance behavior
Official title: The role of valence encoding amygdala ensembles in avoidance behavior
Funded at University of Washington · NIH-11032427 · Data updated 2026-11-12
This study looks at how certain brain cells in the amygdala help us decide whether to move toward or away from things that make us feel good or bad, and it aims to find new ways to help people with anxiety feel better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $148,403 |
| NIH project number | 1K99DA062328-01 |
| Project ID | NIH-11032427 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing anxiety or avoidance behaviors.
✕Less likely to help
Patients without anxiety disorders or those not exhibiting avoidance behaviors may not benefit from this research.
What this research studies
This research investigates how specific groups of neurons in the amygdala, a brain region involved in emotional responses, help determine whether we approach or avoid certain stimuli. By using advanced imaging techniques, the researchers will observe the activity of these neurons in response to both positive and negative experiences. The goal is to understand the mechanisms behind avoidance behavior, which is crucial for survival and can impact conditions like anxiety. Patients may benefit from insights that could lead to new treatments for anxiety-related disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for anxiety and other disorders related to avoidance behavior.
How similar studies have gone: Previous research has shown promising results in understanding brain mechanisms related to emotional responses, suggesting potential for success in this area.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Piantadosi, Sean Christopher — University of Washington
- Study coordinator: Piantadosi, Sean Christopher
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.