Understanding how the brain predicts threats over time
Official title: Norepinephrine and second messenger encoding of temporal threat proximity
Funded at Yale University · NIH-10997850 · Data updated 2026-11-12
This study looks at how our brains recognize and prepare for potential dangers, focusing on how certain chemicals help us predict these threats, which could lead to better treatments for anxiety and trauma-related issues like PTSD.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31MH138088-01 |
| Project ID | NIH-10997850 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing anxiety disorders or PTSD who are interested in understanding their condition better.
✕Less likely to help
Patients with no history of anxiety or trauma-related disorders may not receive direct benefits from this research.
What this research studies
This research investigates how the brain processes and predicts potential threats in the environment, focusing on the role of norepinephrine and cyclic AMP in encoding the timing of these threats. By studying the neural mechanisms in the prefrontal cortex, the research aims to uncover how accurate threat predictions can help prevent psychiatric disorders like PTSD. The approach involves examining how the brain links predictive cues to future threats and how this affects defensive behaviors. Patients may benefit from insights that could lead to improved treatments for anxiety and trauma-related disorders.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients suffering from anxiety and PTSD.
How similar studies have gone: Previous research has shown promising results in understanding the neural mechanisms of threat prediction, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Basu, Aakash — Yale University
- Study coordinator: Basu, Aakash
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.