Understanding how the brain organizes sound frequency processing
Cellular and Molecular Basis of Tonotopic Map Formation in the Mouse Cochlear Nucleus
This study is looking at how certain molecules in the brain help organize the way we hear different sounds, using special mice to learn more about this process, which could eventually help people with hearing problems.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loyola University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10640620 on NIH RePORTER |
What this research studies
This research investigates the cellular and molecular mechanisms that form tonotopic maps in the auditory system, which are essential for sound frequency discrimination. By studying mutant mice, the researchers aim to uncover how specific signaling molecules, like ephrins and Eph receptors, contribute to the organization of auditory neurons. The project focuses on understanding the role of these molecules in maintaining the precision of sound processing in the cochlear nucleus. Insights gained from this research could help in understanding auditory dysfunctions and disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with auditory processing disorders or related hearing difficulties.
Not a fit: Patients with normal auditory processing and no hearing issues may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for auditory processing disorders, enhancing patients' ability to discriminate sounds.
How similar studies have performed: Previous studies have shown success in understanding similar mechanisms in other sensory systems, suggesting potential for breakthroughs in auditory research.
Where this research is happening
Chicago, United States
- Loyola University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Yu, Wei-Ming — Loyola University of Chicago
- Study coordinator: Yu, Wei-Ming
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.