Understanding how the brain makes decisions based on rewards

Value networks and hippocampal non-local representations

NIH-funded research University of California, San Francisco · NIH-11124818

This study looks at how our brains help us make smart choices and learn from rewards, focusing on how we remember places and past experiences to guide our decisions, and it's designed for anyone interested in understanding how we navigate our world.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of California, San Francisco NIH-funded
Lab location1 site (San Francisco, United States)
Project IDNIH-11124818 on NIH RePORTER

What this research studies

This research investigates the neural mechanisms that underlie intelligent decision-making and learning driven by rewards. It focuses on how animals, including humans, use internal models to navigate complex environments and make choices that lead to future rewards. By studying the hippocampus, the research aims to uncover how it generates representations of different locations and evaluates potential options based on past experiences and rewards. The approach involves observing brain activity in animal models to understand the processes involved in adaptive behavior and decision-making.

Who could benefit from this research

Good fit: Ideal candidates for participation or benefit from this research would include individuals with cognitive impairments or decision-making difficulties.

Not a fit: Patients with conditions unrelated to cognitive function or decision-making may not receive any benefit from this research.

Why it matters

Potential benefit: If successful, this research could enhance our understanding of decision-making processes, potentially leading to improved treatments for conditions related to cognitive and behavioral disorders.

How similar studies have performed: Previous research has shown success in understanding decision-making processes through similar approaches, indicating a promising avenue for further exploration.

Where this research is happening

San Francisco, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.