Understanding how the brain learns to adapt behavior in uncertain situations
Cortico-Amygdalar Substrates of Adaptive Learning
This study looks at how people with Substance Use Disorder make choices and why it can be hard for them to adapt to new situations, focusing on how certain parts of the brain work together to help with decision-making.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11052573 on NIH RePORTER |
What this research studies
This research investigates how individuals with Substance Use Disorder (SUD) struggle with making consistent choices due to difficulties in adapting their learning models. It explores the brain's ability to evaluate different internal models and make decisions under uncertainty, focusing on specific brain regions like the prefrontal cortex and the amygdala. By examining how these areas interact during learning, the research aims to uncover the mechanisms behind adaptive behavior and decision-making in changing environments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Substance Use Disorder who experience challenges in decision-making and learning.
Not a fit: Patients without Substance Use Disorder or those who do not exhibit difficulties in adaptive learning may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for individuals with Substance Use Disorder by enhancing their decision-making and adaptive learning capabilities.
How similar studies have performed: Previous research has shown promising results in understanding brain mechanisms related to learning and decision-making, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Izquierdo, Alicia — University of California Los Angeles
- Study coordinator: Izquierdo, Alicia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.