Understanding how the brain functions during opioid withdrawal
Functional connectivity mechanisms of opioid abstinence
This study is looking at how the brain works in people with opioid use disorder to see how it affects sticking to treatment and avoiding relapse, so we can find better ways to help individuals recover while they’re using medications like methadone or buprenorphine.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11128759 on NIH RePORTER |
What this research studies
This research investigates the brain mechanisms involved in opioid use disorder (OUD) and how they relate to treatment adherence and relapse during early medication-assisted treatment. By analyzing brain networks in a diverse group of individuals receiving methadone or buprenorphine, the study aims to identify patterns that predict both illicit opioid use and adherence to treatment. The approach utilizes advanced network-based analysis to uncover critical insights into the neurobiological factors influencing recovery from OUD. This understanding could lead to the development of more effective interventions tailored to individual needs.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with opioid use disorder who are in the early stages of medication-assisted treatment.
Not a fit: Patients who are not currently undergoing treatment for opioid use disorder or those with severe co-occurring mental health disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that enhance adherence and reduce relapse rates in individuals with opioid use disorder.
How similar studies have performed: Previous research has successfully identified brain networks associated with relapse in opioid use disorder, indicating that this approach has potential for meaningful insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Yip, Sarah — Yale University
- Study coordinator: Yip, Sarah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.