Understanding how the brain forms and recalls memories
Neuronal mechanisms of human episodic memory
This study is looking at how our brains make and remember memories, which helps us make decisions, by observing brain activity in people with epilepsy who haven't found relief from their symptoms, with the hope of finding new ways to help those with memory problems.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10905000 on NIH RePORTER |
What this research studies
This research investigates the neural mechanisms behind how humans form and recall memories, which is crucial for decision-making. By recording activity from single neurons in the brains of patients with drug-resistant epilepsy, the team aims to uncover how memories are created and utilized. The study employs advanced techniques such as in-vivo recordings, electrical stimulation, and computational modeling to explore how memories are stored and how they influence our choices. The goal is to develop new treatments for memory disorders based on these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with drug-resistant epilepsy who are undergoing treatment and can provide insights into memory function.
Not a fit: Patients without memory disorders or those not undergoing treatment for epilepsy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for individuals suffering from memory disorders.
How similar studies have performed: Previous research has shown promising results in understanding memory mechanisms, but this approach of in-vivo recordings in humans is relatively novel.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Rutishauser, Ueli — Cedars-Sinai Medical Center
- Study coordinator: Rutishauser, Ueli
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.