Understanding how the brain fights infections like Toxoplasma gondii
Caspase-8 mediated control of CNS infection
['FUNDING_R01'] · UNIVERSITY OF VIRGINIA · NIH-10978952
This study is looking at how a special protein in the brain helps fight off infections from a common parasite while keeping important brain cells safe, and it's aimed at understanding this process better to help people with similar infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-10978952 on ClinicalTrials.gov |
What this research studies
This research investigates how the brain's immune system controls infections caused by the parasite Toxoplasma gondii, which affects a significant portion of the population. It focuses on the role of a protein called caspase-8, which is crucial for programmed cell death, in managing these infections while preserving vital brain cells. By studying mice with and without caspase-8, researchers aim to uncover the mechanisms that allow the brain to combat these pathogens effectively. The findings could lead to new insights into how the brain protects itself during infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with compromised immune systems or those at risk of CNS infections, particularly those related to Toxoplasma gondii.
Not a fit: Patients with infections not related to Toxoplasma gondii or those without any CNS involvement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for CNS infections, enhancing patient outcomes and brain health.
How similar studies have performed: Previous research has shown that understanding immune responses in the brain can lead to significant advancements in treating CNS infections, suggesting that this approach has potential for success.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HARRIS, TAJIE H. — UNIVERSITY OF VIRGINIA
- Study coordinator: HARRIS, TAJIE H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immunodeficiency Syndrome