Understanding how the brain develops and connects neurons over time
Official title: A Connectomic Analysis of a Developing Brain Undergoing Neurogenesis
Funded at University of Massachusetts Amherst · NIH-10909319 · Data updated 2026-11-12
This study is looking at how the brain grows and changes as new brain cells are made, using a special sea creature called Berghia stephanieae, to help us learn more about how brain networks develop, which could be useful for understanding brain issues that happen when development goes wrong.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Massachusetts Amherst NIH-funded |
| Lab location | 1 site (Hadley, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $605,441 |
| NIH project number | 5R01NS133654-02 |
| Project ID | NIH-10909319 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals under 21 years old who may be affected by neurological conditions or are interested in brain development.
✕Less likely to help
Patients with fully developed brains or those over 21 years old may not benefit directly from this research.
What this research studies
This research investigates the development of neural circuits in the brain as new neurons are formed and integrated into existing networks. Using a unique animal model, the mollusc Berghia stephanieae, researchers will create detailed wiring diagrams of the brain at various stages of development. By tracking changes in specific neurons and their connections, the study aims to uncover fundamental insights into how brain networks grow and adapt, which could help in understanding neurological conditions linked to improper brain development.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment of neurological conditions related to brain development.
How similar studies have gone: While this approach is novel in its specific application to the mollusc model, similar studies in other species have shown promise in understanding brain development.
Where this research is happening
-
University of Massachusetts Amherst
Hadley, United States Active
Researchers
- Principal investigator: Katz, Paul S — University of Massachusetts Amherst
- Study coordinator: Katz, Paul S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.