Understanding how the brain detects unusual visual information
Official title: Circuits for deviance detection in V1
Funded at Nathan S. Kline Institute for Psych Res · NIH-11199823 · Data updated 2026-11-12
This study looks at how the brain of mice notices unexpected visual changes, which could help us understand why some people have trouble processing what they see due to certain brain conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nathan S. Kline Institute for Psych Res NIH-funded |
| Lab location | 1 site (Orangeburg, United States) |
| Project start | October 3, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $392,356 |
| NIH project number | 7R01EY033950-04 |
| Project ID | NIH-11199823 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for potential benefit include individuals with neurological or psychiatric disorders that affect visual processing.
✕Less likely to help
Patients without any neurological or psychiatric conditions affecting visual perception may not receive direct benefits from this research.
What this research studies
This research investigates how the brain's primary visual cortex (V1) responds to visual stimuli that deviate from expected patterns. By studying the neural activity in mice, the researchers aim to uncover the underlying circuitry involved in this 'deviance detection' process. The study utilizes advanced genetic and optical tools to explore how different types of neurons interact to enhance the brain's ability to recognize important visual changes. Insights gained could help understand visual processing deficits in various neurological and psychiatric disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of visual processing issues in individuals with neurological and psychiatric conditions.
How similar studies have gone: Previous research has shown promising results in understanding deviance detection in animal models, suggesting potential for similar insights in human conditions.
Where this research is happening
-
Nathan S. Kline Institute for Psych Res
Orangeburg, United States Active
Researchers
- Principal investigator: Hamm, Jordan P — Nathan S. Kline Institute for Psych Res
- Study coordinator: Hamm, Jordan P
Related research
Other NIH-funded projects on the same topics.
-
Understanding how brain activity changes may drive Alzheimer’s disease progression in a mouse model
Researchers are testing how changes in brain signals and protein cleanup processes affect the development of Alzheimer’s disease in mice.
-
Addressing racial disparities in opioid overdose deaths using open source peer recovery coaching and AI-powered mobile health
A small, open-source program uses AI-powered texting and peer recovery coaching to help Black and Latinx people who use opioids access support and stay in treatment, aiming to reduce overdose deaths and close gaps in care.
-
Hyperexcitability in Alzheimer's Disease and how it affects brain signals
Aimed at people with Alzheimer’s disease or related dementia, this grant studies abnormal brain activity that happens early in the disease and tests whether stopping it can help cognition and amyloid buildup.
-
Understanding how a brain visual pathway linked to social cues goes wrong in schizophrenia
Aiming to map and understand how a special brain visual pathway that helps read social cues may be disrupted in people with schizophrenia, to identify potential targets for future treatments.
-
Circuits for detecting surprising events in V1 (visual cortex)
This grant studies how the brain automatically notices unexpected visual events, focusing on autism-related brain processing, to understand how people with autism may experience and react to their surroundings.
-
CB1 signaling and alcohol effects in development
This project studies how alcohol exposure before birth changes brain signaling and behavior later in life, with a focus on CB1 receptors in the hippocampus and prefrontal cortex.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.