Understanding how the brain controls speech generation

Neural control of speech generation in human motor cortex

['FUNDING_OTHER'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10890159

This study is exploring how the brain helps us talk, with the goal of creating new technology that can help people who have trouble speaking communicate better.

Quick facts

Phase['FUNDING_OTHER']
Study typeNih_funding
SexAll
SponsorMASSACHUSETTS GENERAL HOSPITAL (nih funded)
Locations1 site (BOSTON, UNITED STATES)
Trial IDNIH-10890159 on ClinicalTrials.gov

What this research studies

This research investigates the neural mechanisms involved in speech generation by examining the motor cortex of the brain. It aims to develop advanced brain-computer interfaces that can help individuals with speech disabilities communicate more effectively. The project will analyze how specific neural patterns correspond to spoken words and how context influences these patterns. By leveraging cutting-edge computational tools, the research seeks to translate neural signals into actionable communication outputs.

Who could benefit from this research

Good fit: Ideal candidates for this research include individuals with speech disorders due to conditions like amyotrophic lateral sclerosis or stroke.

Not a fit: Patients with intact speech capabilities or those whose speech disorders are not related to neurological conditions may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could significantly enhance communication abilities for individuals with speech impairments caused by neurological conditions.

How similar studies have performed: Previous research has shown promise in using neural decoding techniques for communication, indicating that this approach could lead to significant advancements in assistive technologies.

Where this research is happening

BOSTON, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Conditions: Amyotrophic Lateral Sclerosis Motor Neuron Disease

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.