Understanding how the brain controls REM sleep
Medullary Control of REM Sleep
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10654638
This study is looking at how certain brain cells that help control REM sleep, which is important for dreaming and can affect mood disorders like depression, work and connect with other parts of the brain, to better understand how sleep problems might relate to mood issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10654638 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific neurons in the medulla part of the brain that are involved in regulating rapid eye movement (REM) sleep, which is linked to dreaming and mood disorders like depression. Using advanced techniques, researchers will map the neural circuits and study how these neurons influence REM sleep patterns. The study focuses on genetically defined neurons that release corticotropin-releasing hormone (CRH) and aims to uncover their activity during sleep and their connections to other brain areas. By understanding these mechanisms, the research hopes to shed light on the relationship between REM sleep disturbances and mood disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing mood disorders, particularly those with symptoms related to disrupted REM sleep.
Not a fit: Patients who do not have mood disorders or REM sleep disturbances may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for mood disorders by targeting the mechanisms that control REM sleep.
How similar studies have performed: Previous studies have shown promising results in understanding the role of brain circuits in sleep regulation, making this research a continuation of established findings.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEBER, FRANZ L — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: WEBER, FRANZ L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.