Understanding how the brain controls executive functions using advanced technology
Official title: Neocortical microarchitecture of executive function using large-scale intracranial electrophysiology
Funded at University of Colorado Denver · NIH-10933716 · Data updated 2026-11-12
This study is looking at how our brains make decisions and solve problems by using a special device to track brain activity, and it's aimed at helping people understand and treat cognitive disorders better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | August 19, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,018,155 |
| NIH project number | 1R61DC021924-01 |
| Project ID | NIH-10933716 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals undergoing deep brain stimulation for neurological conditions, particularly those with cognitive impairments.
✕Less likely to help
Patients who do not have cognitive disorders or are not undergoing deep brain stimulation may not benefit from this research.
What this research studies
This research investigates the neural mechanisms behind executive functions, such as decision-making and conflict resolution, by utilizing a cutting-edge device called the Neuropixels probe. This probe allows for the simultaneous recording of activity from hundreds of neurons in the human brain, specifically in the dorsolateral prefrontal cortex. By analyzing brain activity during specific cognitive tasks, the research aims to uncover how different brain regions interact and respond to various challenges. This could lead to a deeper understanding of cognitive disorders and improve treatment strategies.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cognitive disorders like Alzheimer's disease and lead to better therapeutic approaches.
How similar studies have gone: While the use of advanced electrophysiological techniques in humans is still emerging, similar approaches have shown promise in animal models and preliminary human studies.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Kramer, Daniel R — University of Colorado Denver
- Study coordinator: Kramer, Daniel R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.