Understanding how the brain and gut communicate to regulate metabolism
Internal State Sensing Via The Gut-Brain Axis
This study is looking at how the brain and gut work together to manage energy in our bodies, especially how our senses can affect metabolism, and it aims to help people understand conditions like diabetes and heart disease as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10670336 on NIH RePORTER |
What this research studies
This research investigates the connection between the brain and gut in regulating energy metabolism, particularly how sensory information influences metabolic processes. Using a model organism called C. elegans, the study aims to uncover the mechanisms of neuroendocrine communication that can lead to metabolic disorders. The researchers focus on identifying specific neuronal circuits and peptides that play a role in this communication, which could provide insights into diseases like diabetes and cardiovascular issues. By exploring these interactions, the research seeks to enhance our understanding of metabolic dysregulation and its impact on aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing metabolic disorders or age-related diseases such as diabetes or cardiovascular conditions.
Not a fit: Patients with metabolic conditions unrelated to the gut-brain axis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related metabolic diseases.
How similar studies have performed: Previous research has shown promising results in understanding the gut-brain axis and its role in metabolism, indicating that this approach has potential for significant findings.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Srinivasan, Supriya — Scripps Research Institute, the
- Study coordinator: Srinivasan, Supriya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.