Understanding how the brain adapts metabolically after a traumatic injury
Mechanisms of metabolic adaptation after traumatic brain injury
This study is looking at how the brain adapts its energy use after a traumatic brain injury to help with healing, focusing on special brain cells that might protect nerve cells and support recovery, which could lead to better treatments for people with TBI.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10555255 on NIH RePORTER |
What this research studies
This research investigates how the brain changes its metabolism following a traumatic brain injury (TBI) to support recovery. It focuses on the role of astrocytes, a type of brain cell, in utilizing fatty acids for energy, which may help protect neurons and promote healing. By using specialized mouse models, the researchers aim to uncover the specific metabolic processes that occur after TBI and how they can be harnessed to improve recovery outcomes for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a traumatic brain injury and are seeking potential new therapies for recovery.
Not a fit: Patients with non-traumatic brain injuries or those who do not have metabolic issues related to brain recovery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance recovery and reduce disabilities in patients with traumatic brain injuries.
How similar studies have performed: Previous research has shown promising results in understanding metabolic adaptations in the brain after injury, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Scafidi, Susanna — Johns Hopkins University
- Study coordinator: Scafidi, Susanna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.