Understanding how the brain adapts after limb loss or stroke

The Mechanisms and Functional Consequences of Interhemispheric Plasticity

NIH-funded research Henry M. Jackson Fdn for the Adv Mil/med · NIH-10843864

This study looks at how the brain adjusts after things like losing a limb or having a stroke, and it hopes to find out if these changes help people recover or lead to ongoing pain, which could help improve treatment for patients.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionHenry M. Jackson Fdn for the Adv Mil/med NIH-funded
Lab location1 site (Bethesda, United States)
Project IDNIH-10843864 on NIH RePORTER

What this research studies

This research investigates how the brain changes its neural activity following events like limb amputation or stroke. By using advanced imaging techniques and animal models, the study aims to identify the specific neurons and synapses involved in these adaptations. The goal is to determine whether these brain changes help in recovery or contribute to chronic pain conditions. Patients may benefit from insights that could improve rehabilitation strategies and pain management.

Who could benefit from this research

Good fit: Ideal candidates for this research include adults who have experienced limb amputation, nerve damage, or stroke.

Not a fit: Patients with conditions unrelated to limb loss, stroke, or chronic pain may not receive any benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to better rehabilitation techniques and pain management strategies for individuals recovering from limb loss or stroke.

How similar studies have performed: Previous research has shown promising results in understanding brain plasticity, suggesting that this approach could yield valuable insights.

Where this research is happening

Bethesda, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.