Understanding how the bone marrow's structure affects blood cell production in a specific blood cancer.
The bone marrow extracellular matrix: scaffold of hematopoiesis
This study is looking at how the environment around blood cells in the bone marrow affects the progression of Primary Myelofibrosis, a type of blood cancer, to find new ways to improve treatment for patients like you.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10576364 on NIH RePORTER |
What this research studies
This research investigates the role of the bone marrow extracellular matrix (ECM) in the disease mechanisms of Primary Myelofibrosis (PMF), a serious blood cancer. The study aims to explore how abnormal interactions between blood cells and the ECM contribute to the disease's progression. By focusing on integrins, which are molecules that help cells attach to the ECM, the research seeks to identify new therapeutic targets that could improve treatment outcomes for patients with PMF. The approach includes analyzing both mouse and human samples to better understand the disease's biology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Primary Myelofibrosis who may be seeking alternative treatment options.
Not a fit: Patients with other types of blood disorders or those who do not have Primary Myelofibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that specifically target the bone marrow environment, potentially improving survival rates and quality of life for patients with PMF.
How similar studies have performed: While there has been significant research on gene mutations in PMF, this approach focusing on the ECM is relatively novel and has not been extensively tested.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Matsuura, Shinobu — Boston University Medical Campus
- Study coordinator: Matsuura, Shinobu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.