Understanding how the bone marrow environment affects blood cell production
Official title: The microenvironment in bone marrow hematopoiesis
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11034384 · Data updated 2026-11-12
This study is looking at how the special environment in your bone marrow helps make different types of blood cells, which could lead to new ways to treat blood disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2031 |
| Funding year | 2025 |
| Award (this year) | $1,123,357 |
| NIH project number | 1R35HL177125-01 |
| Project ID | NIH-11034384 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with blood disorders or conditions affecting blood cell production.
✕Less likely to help
Patients with stable blood cell production and no underlying blood disorders may not benefit from this research.
What this research studies
This research investigates the unique environment within the bone marrow that supports the production of blood cells. It focuses on how specialized structures within the marrow influence the differentiation of stem cells into various blood cell types, such as lymphocytes and red blood cells. By using advanced imaging techniques, the research aims to uncover the spatial organization of these structures and their roles in normal and stressed conditions. This knowledge could lead to new strategies for manipulating blood cell production to treat various blood disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for blood disorders by enhancing our understanding of blood cell production.
How similar studies have gone: Other research has shown success in understanding the bone marrow microenvironment, but this specific approach is novel and aims to provide deeper insights.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Lucas, Daniel — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Lucas, Daniel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.