Understanding how the body's own enzymes affect blood clotting and inflammation in sepsis
PROJECT 1 - Host Neuraminidases in Hemostasis and Sepsis
This research explores how natural enzymes in our bodies contribute to blood clotting and inflammation during sepsis, a life-threatening condition.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11110312 on NIH RePORTER |
What this research studies
Sepsis is a severe illness where the body's response to infection causes organ damage, often leading to death or long-term health problems. Despite its seriousness, effective treatments for sepsis are still lacking. This project looks into a newly discovered process where certain proteins in the blood are changed by enzymes, affecting how long they last and how they function. We believe that changes in this process during sepsis can impact blood clotting and inflammation, which are key factors in the disease.
Who could benefit from this research
Good fit: This foundational research is focused on understanding disease mechanisms and does not currently involve direct patient participation, but future studies based on this work may seek patients with sepsis.
Not a fit: Patients not experiencing sepsis or related conditions would not directly benefit from this specific research at its current stage.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of sepsis and potentially new ways to treat the severe blood clotting and inflammation it causes.
How similar studies have performed: This project explores a recently discovered mechanism of glycoprotein remodeling, suggesting a novel approach to understanding sepsis pathophysiology.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Marth, Jamey — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Marth, Jamey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.